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Vascular endothelial growth factor, commonly abbreviated VEGF, denotes a family of signaling proteins with major roles in vascular development and remodeling. Binding to the appropriate receptors changes endothelial-cell behavior, including growth, survival or movement.

Its effect depends on location, timing and receptor context. A spatially organized signal can guide construction of a network, whereas simply increasing the concentration everywhere need not create correctly patterned functional blood vessels.