Importin 2026-10-18
Nuclear localization sequence 2026-10-18
A nuclear localization sequence is an ordered stretch of amino acid residues that can direct protein import into a cell nucleus. In the classical pathway, importin α recognizes the nuclear localization sequence, and importin β mediates passage through the nuclear pore complex. Other recognition pathways exist. An exposed nuclear localization sequence is a targeting feature, not a guarantee of import under every condition.[ref]
RNA export is a different cargo pathway: RNA travels associated with proteins, as a ribonucleoprotein, rather than being imported by its own nuclear localization sequence. Export of messenger RNA connects nuclear transcription to cytoplasmic biological translation.[ref]
The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper. Transport of RNAs, opening paragraphs