A protein that binds appropriate iron-responsive elements depending on cellular state. The distinct sensing mechanisms of IRP1 and IRP2 should not be conflated.
An iron-responsive RNA-binding protein whose abundance is controlled through regulated degradation, including by FBXL5. It does not use the aconitase switch of IRP1.
A bifunctional protein that acts as cytosolic aconitase with an appropriate iron–sulfur cluster and as an iron-responsive RNA-binding protein when converted to its RNA-binding state.[ref]

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  1. Iron homeostasis
  2. Biology
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