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Incoming links: J. Tapanainen
J. Tapanainen 2026-11-05
J. Tapanainen is the first author of a 1991 study of steroid production in cultured human granulosa-lutein cells. The team compared 48-hour cultures with and without human chorionic gonadotropin or follicle-stimulating hormone, measuring several steroids and assaying aromatase activity separately.[ref]
Regulation of steroid and steroid sulfate production and aromatase activity in cultured human granulosa-luteal cells by J. Tapanainen and others. Abstract: culture design and measured endpoints
Both hormones increased pregnenolone and progesterone production substantially, while changes in several other steroid products were small. This illustrates why one hormone measurement cannot summarize a whole biochemical pathway: different reaction steps can impose different constraints. Separate measurements of products and enzyme activity make the proposed regulation experimentally testable, while the cultured-cell result remains distinct from a complete account of ovarian function in an animal.[ref]
Regulation of steroid and steroid sulfate production and aromatase activity in cultured human granulosa-luteal cells by J. Tapanainen and others. Abstract: differential steroid responses and aromatase regulation; Journal of Steroid Biochemistry and Molecular Biology 39, 19–25, 1991