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Joined 2026-09-21 Message
Incoming links: KRAS G12C protein
AMG 510 Created 2026-10-20 Updated 2026-11-05
A covalent inhibitor developed against KRAS G12C protein, also called sotorasib. Its state-dependent binding illustrates targeting a mutant small GTPase outside the nucleotide site.[ref]
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity by Jude Canon and others. Chemical and preclinical characterization