Laura E. Niklason is a physician and biomedical engineer whose research develops methods for constructing functional vascular and lung tissues. The Yale profile describes this research, and the full author byline of the follow-up artery paper verifies the E. initial.[ref]
Laura Niklason profile by Yale School of Medicine. Biography and research headings; linked follow-up byline
Niklason led the author list of the 1999 report of functional arteries grown in vitro.[ref]
Functional arteries grown in vitro by L. E. Niklason and others. Primary byline
Its scientific aim goes beyond producing a tube of cells: cultured tissue must acquire organized structure and measurable function. The approach connects vascular cell culture with a controlled bioreactor environment, then asks how the resulting construct performs.Two useful distinctions follow. First, a vessel’s mechanical response depends on its geometry and the extracellular matrix formed during culture, not only on the starting tissue-engineering scaffold. Second, the presence of viable cells is different from evidence that they have the intended differentiated function. Measuring organization, transport and mechanical behavior together helps connect a culture method to the biological task. These are testable engineering questions rather than conclusions that follow from tissue appearance alone.
- Functional arteries grown in vitro by L. E. Niklason and others
- Laura Niklason profile by Yale School of Medicine
- Morphologic and mechanical characteristics of engineered bovine arteries by Laura E. Niklason and others
- Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells by Jinming Gao and others
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