The cultured epithelial model can form polarized layers or epithelial cysts, making it useful for testing vesicle trafficking and apical-basal organization. Cell-line origin, culture geometry and the particular clone matter when comparing results across experiments. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 12, 18 and 19, compartments, division and cell junctions
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