Quantitative analysis of how local changes in reaction capacities alter steady-state metabolic fluxes and concentrations. Its sensitivities depend on the operating condition rather than identifying one invariant limiting step.
Under the scaling assumptions of metabolic control analysis, the complete set of independently scaled reaction-capacity flux control coefficients for one steady-state flux sums to one. Uniformly scaling all capacities scales the flux, and differentiation with respect to the scale factor gives the sum.
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Metabolic Control Analysis (MCA) is a theoretical framework used to study the regulation of metabolic pathways and understand how different factors influence the rates of metabolic reactions. Developed in the 1970s by biochemists, particularly by the work of A.P. (Pavel) Kacser and others, MCA provides a quantitative approach to analyze the control and efficiency of metabolic processes.