Past exam of the mathematics course of the University of Cambridge / 2014 / iii / Paper 35 / 4 / e

The overall mean $\mu$ and the between-study heterogeneity $\tau$ encode different information. A proper broad normal distribution prior such as $\mu \sim N(0,2^2)$ is one possible weak prior for the mean log odds ratio; information about the spread of trials alone does not determine its center.

A concrete prior calibration for normal random-effect range can make the factor-of-50 statement simultaneous across all six trials. Conditional on $\tau$, each pair difference has normal distribution ${\beta }_j-{\beta }_k\sim N(0,2{\tau }^2)$. Set $R=\log 50$, $m=\left(\genfrac{}{}{0ex}{}{6}{2}\right)=15$, $z={\Phi }^{-1}(1-0.05/(2m))$ andFor every $\tau \le A$, each pair exceeds $R$ in absolute value with probability at most $0.05/m$. The union bound therefore gives $\mathbb{P}({\max }_j{\beta }_j-{\min }_j{\beta }_j>R)\le 0.05$, and integrating over the uniform prior preserves that bound. This is one explicit interpretation of “very unlikely”; a different elicited probability would change the bound. A smoother proper scale prior could be calibrated similarly.

The proposed $1/\tau$ improper prior is unsuitable. The observed-data likelihood function approaches the positive common-effect likelihood as $\tau \downarrow 0$. After restricting $\mu$ and the intercepts to a compact interior region, it is bounded below there by a positive constant. HenceThis is an improper posterior from a log-uniform random-effect scale prior. Proper conditional sampling distributions do not repair the improper joint posterior, and an arbitrary tiny cutoff would make inference depend on that cutoff.