Past exam of the mathematics course of the University of Cambridge / 2018 / iii / Paper 207 / 1 / b

Use an irreversible continuous-time multi-state model $1\to 2\to 3$, with state 3 absorbing. Let $a=q_{12}(50)$ and $b=q_{23}(50)$, and define log-linear age effects byFor a closed-form panel-observed multi-state likelihood, freeze the age covariate at the start of each observation interval. The transition intensities are then $(a,b)$ over the first interval and $(\lambda ,\mu )=(a{e}^{5{\beta }_{12}},b{e}^{5{\beta }_{23}})$ over the second. Conditional on the initial state, the likelihood contribution isIndeed, $p_{11}(5)=e^{-5a}$ and $p_{13}(1)=1-p_{11}(1)-p_{12}(1)$. In this irreversible continuous-time Markov chain, the intermediate state has probabilityThe second expression is the continuous limit of the first and handles equal rates. The observed two-state jump across an interval is compatible with adjacent instantaneous transitions: an unobserved visit to state 2 occurs between the examinations.

The four-parameter panel-observed multi-state likelihood requires the following additional assumptions.

If age is instead updated continuously, the model is time-inhomogeneous and the displayed homogeneous transition formula is not exact. For example, setThen the exact irreversible likelihood contribution isThus the simple closed form uses an explicit frozen-age approximation; adjacency alone and continuously evolving age do not determine that form.