For an affine morphism and a quasi-coherent sheaf , every inverse image of an affine open is affine. Higher cohomology of a quasi-coherent sheaf on an affine scheme vanishes, so
The Leray spectral sequence therefore has only its zeroth row, and its edge maps give
For , the Mayer-Vietoris sequence for sheaf cohomology is the long exact sequence
We prove the required vanishing by induction on the number of open sets. The case is an assumption. Put and . The induction hypothesis gives for every . The intersections cover , and every nonempty finite intersection among them is one of the intersections in the hypothesis, so the same induction gives . We also have . Exactness of the Mayer-Vietoris sequence now yields
The finite complex computing cohomology in a proper flat family gives a bounded complex of finite locally free -modules such that, for every -module ,
In particular, computes and computes .
Since for , the finite exact tail above degree can be split successively: its last differential is surjective onto a projective module, hence splits, and induction moves left. Removing the resulting contractible summands leaves a finite locally free complex ending in degree . Therefore
and after tensoring with the same formula computes the fiber cohomology.
If , the last differential is surjective, and remains so after every base change; hence every vanishes. Conversely, if all fiber groups vanish, the finitely generated cokernel satisfies for every . Localizing and applying Nakayama lemma gives for every , so . Thus
Take an affine open subscheme . Properness and flatness survive base change, and is reduced because is reduced. A bounded complex of finite locally free modules computes the cohomology of on .
If some were nonzero, choose the largest such . All groups above degree would vanish, while every fiber group in degree vanishes by hypothesis. Part (iii) would force , a contradiction. Hence
for every affine and every . These groups compute the sections of the higher direct images over affine opens, so for all , including when . The Leray spectral sequence now gives

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