One standard construction uses the Debiased Lasso. Starting from the Square-root Lasso estimate , estimate a vector that approximately inverts the th column of the empirical Gram matrix , for example by a Nodewise Lasso. Define
and estimate by . The approximate two-sided level- test rejects when
where is a standard normal quantile.
Sufficient high-dimensional conditions include a Compatibility condition for the Lasso bounded away from zero, , , and
together with the corresponding sparsity and consistency conditions for the nodewise inverse-Gram estimate. Under these assumptions the Debiased-Lasso asymptotic normality makes the rejection probability under tend to .

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