There are serious philosophical reasons to resist inferring the literal truth of every successful theoretical description. Those reasons support a selective and revisable attitude; they do not establish that none of the unobservable entities investigated by science exists.
Pessimistic induction starts from successful earlier theories whose central ontological claims were later rejected. Their history challenges an unrestricted inference from predictive success to truth. For example, successful descriptions of light transmission were once combined with an account involving a mechanical luminiferous aether. Continued use of some mathematical relations does not show that the proposed medium was real. The force of the objection depends on which part of a theory produced its successful predictions, not on collecting a list of old mistakes.[ref]
Scientific underdetermination supplies a different challenge. Agreement with available data can leave rival accounts open. If they are empirically equivalent throughout a specified domain, another experiment restricted to that domain cannot discriminate them. This limits what those data establish. It does not show that every actual theoretical disagreement is permanently undecidable, or that equally compatible models must receive equal confidence given all relevant background evidence.
The realist reply emphasizes convergence across independent ways of detecting and manipulating a putative entity. An electron is not supported by one formula alone: accounts of its electric charge, scattering and response to fields connect different apparatuses and phenomena. Such success can be a reason to infer a common physical cause. The no-miracles argument expresses that explanatory motivation, but its force is abductive rather than deductive. It must not assume that only a literally true total theory could produce any success.
Several qualified positions remain defensible. Entity realism places particular weight on robust experimental use of entities without endorsing every theoretical account of them. Structural realism emphasizes specified relations retained across theory change. Neither label removes the need to identify what experimental interventions establish or which interpreted structure survives. Preserving an equation's shape alone is insufficient if the meanings and tested domains have changed.[ref]
Constructive empiricism offers a genuine alternative: accept a theory's empirical adequacy while withholding belief in its full account of unobservables. The realist must explain why stronger belief is warranted, rather than accuse this stance of denying ordinary laboratory success.
A defensible realism therefore concerns particular well-supported claims, mechanisms and relations, with explicit domains and error allowances. It recognizes historical revision without treating every surviving term as equally secure. Neither universal literal realism nor universal scepticism about entities follows from scientific success or its historical failures.

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