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Autozygosity is homozygosity by descent: the maternal and paternal copies in one individual derive from the same ancestral copy. Unlike ordinary homozygosity, it concerns the ancestry of chromosome copies rather than only their observed states. In a pedigree with one ancestral disease-allele copy and fully penetrant recessive inheritance, every affected individual is autozygous for that copy.

Parametric linkage analysis forms a pedigree likelihood from a specified disease model, including penetrance, allele frequencies and recessive inheritance or another transmission model. It estimates or tests the recombination fraction between a disease locus and a genetic marker.

// Target: biology.bigb