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Joined 2026-09-21 Message
Incoming links: Roger M. Wartell
J. Michael Li 2026-11-05
J. Michael Li is a coauthor, with Xueguang Sun and Roger M. Wartell, of the2007 study of frozen-solution conversion between an RNA hairpin and a metastable RNA dimer. The paper identifies the authors with Georgia Tech's School of Biology and gives Li's byline in this form.[ref]
Conversion of stable RNA hairpin to a metastable dimer in frozen solution by Xueguang Sun and others. Title-page byline and affiliation
The study examined a79-nucleotide RNA with two bands in native gel electrophoresis but one in denaturing conditions. Sedimentation equilibrium supported monomer and dimer assignments. Experiments on shorter segments implicated the first21nucleotides in dimer formation.[ref]
Conversion of stable RNA hairpin to a metastable dimer in frozen solution by Xueguang Sun and others. Abstract and Results, monomer/dimer identification and21-nucleotide segment
A useful distinction follows: two native gel bands alone do not count the number of strands in each structure. Changing the folding state can change electrophoretic mobility without changing strand mass. Combining a mobility observation with an independent association measurement addresses that ambiguity, which is central to interpreting this contribution.
Xueguang Sun 2026-11-05
Xueguang Sun studied the structure and RNA-binding properties of the bacterial protein Hfq. His Georgia Tech doctoral thesis, dated May2006, identifies Roger M. Wartell as his committee chair and documents structural analysis, binding experiments and studies of RNA association.[ref]
Characterization of E coli Hfq structure and its RNA binding properties by Xueguang Sun. Title and approval pages; chaptersII–IV
The thesis combines predicted protein structure with experiments probing RNA binding, including gel electrophoresis and fluorescence anisotropy. That combination tests a structural hypothesis against binding behavior rather than treating a predicted surface as sufficient evidence of its function.[ref]
Characterization of E coli Hfq structure and its RNA binding properties by Xueguang Sun. ChapterIII, sections on gel mobility shift, fluorescence anisotropy and mutant binding
Sun later coauthored the2007 frozen-solution study with J. Michael Li and Wartell, showing that a stable RNA hairpin could convert efficiently into a metastable RNA dimer under freezing conditions.[ref]
These projects connect molecular recognition with competing structures: a protein can present alternative binding surfaces, and an RNA strand can pair internally or associate with another strand. Experiments are needed to distinguish those possibilities; a sequence or a mobility band alone does not specify the resulting complex.