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Let $p:\tilde{M}\to M$ be the universal cover. Its number of sheets is $|{\pi }_1(M)|$, which is finite, so compactness of $M$ makes $\tilde{M}$ compact. As a covering space of a manifold without boundary, it is also a three-manifold without boundary. It is connected and simply connected by the definition of universal cover.

A simply connected manifold is orientable: transport of a local orientation around loops gives the orientation character ${\pi }_1(\tilde{M})\to \{\pm 1\}$, and the trivial fundamental group leaves no orientation obstruction. The degree-one Hurewicz theorem, equivalently the identification of $H_1$ with the abelianization of the fundamental group, gives $H_1(\tilde{M};\mathbb{Z})=0$. The universal coefficient theorem for cohomology then givesbecause the additional term $\mathrm{Ext}(H_0(\tilde{M};\mathbb{Z}),\mathbb{Z})$ vanishes for $H_0\cong \mathbb{Z}$. Integral Poincare duality gives $H_2(\tilde{M};\mathbb{Z})\cong H^1(\tilde{M};\mathbb{Z})=0$. Connectedness gives $H_0\cong \mathbb{Z}$, and the orientation fundamental class gives $H_3\cong \mathbb{Z}$; higher groups vanish by dimension. ConsequentlyThus the universal cover of a closed three-manifold with finite fundamental group is an integral homology sphere. No homeomorphism classification of three-manifolds is needed for this homological conclusion.