Total synthesis of (±)-tirandamycin A by Philip DeShong and others 2026-10-20
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Primary synthetic study. Pages 5220–5221, Schemes II–III, report aqueous hydrogen fluoride conversion of related pyranones into a fused lactone. The accompanying discussion qualifies the relative stereochemistry as a mechanistic assignment rather than an unambiguous assignment from the reported NMR spectroscopy.
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