Yan Chen is the first author of the 1999 photon-counting-histogram study in fluorescence fluctuation spectroscopy. The analysis used the distribution of detected photon counts in short intervals to estimate molecular brightness and the average number of fluorescent molecules in the observation volume.[ref]
The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy by Yan Chen and others. Abstract and model: photon counts per molecule, occupancy and illumination profile
Two samples can have the same mean fluorescence while containing different numbers of molecules with different individual brightnesses. Their count distributions can help distinguish these possibilities when interpreted with the instrument's illumination profile and counting statistics. This entry identifies the researcher through that paper's byline and affiliation, without conflating other scientists named Yan Chen.
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