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Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination by Yasuko Murakami and others Created 2026-10-20 Updated 2026-10-31
Primary source: www.nature.com/articles/360597a0
Cited material: Immunodepletion and purified 26S-proteasome degradation assays, pp. 597–599.
Yasuko Murakami Created 2026-10-20 Updated 2026-11-05
Ornithine decarboxylase converts ornithine to putrescine with release of carbon dioxide, beginning a major route of polyamine biosynthesis. Its regulation includes binding to antizyme, which can inhibit activity and promote protein degradation. This gives a compact example of controlling a metabolic pathway by changing both catalytic availability and enzyme lifetime.