Theory that atoms exist, i.e. matter is not continuous.
Much before atoms were thought to be "experimentally real", chemists from the 19th century already used "conceptual atoms" as units for the proportions observed in macroscopic chemical reactions, e.g. . The thing is, there was still the possibility that those proportions were made up of something continuous that for some reason could only combine in the given proportions, so the atoms could only be strictly consider calculatory devices pending further evidence.
Subtle is the Lord by Abraham Pais (1982) chapter 5 "The reality of molecules" has some good mentions. Notably, physicists generally came to believe in atoms earlier than chemists, because the phenomena they were most interested in, e.g. pressure in the ideal gas law, and then Maxwell-Boltzmann statistics just scream atoms more loudly than chemical reactions, as they saw that these phenomena could be explained to some degree by traditional mechanics of little balls.
Confusion around the probabilistic nature of the second law of thermodynamics was also used as a physical counterargument by some. Pais mentions that Wilhelm Ostwald notably argued that the time reversibility of classical mechanics + the second law being a fundamental law of physics (and not just probabilistic, which is the correct hypothesis as we now understand) must imply that atoms are not classic billiard balls, otherwise the second law could be broken.
Pais also mentions that a big "chemical" breakthrough was isomers suggest that atoms exist.
Very direct evidence evidence:
- Brownian motion mathematical analysis in 1908. Brownian motion just makes it too clear that liquids cannot be continuous... if they were, there would obviously be no Brownian motion, full stop.
- X-ray crystallography: it sees crystal latices
- scanning tunnelling microscope: it sees individual atoms for Christ's sake, what else do you want?
Figure 1. Still from A boy and his atom by IBM. Source.
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Less direct evidence:
- 1874 Isomers suggest that atoms exist
- kinetic theory of gases seems to explain certain phenomena really well
Subtle is the Lord by Abraham Pais (1982) page 40 mentions several methods that Einstein used to "prove" that atoms were real. Perhaps the greatest argument of all is that several unrelated methods give the same estimates of atom size/mass:
- from 1905:
- in light quantum paper
- enabled by experimental work of Wilhelm Pfeffer on producing rigid membranes
- sugar molecules in water
- Brownian motion: investigations on the theory of the Brownian movement by Einstein (1905)
- 1911: blueness of the sky and critical opalescence