She's truly passionate about health research and keeping healthy, almost obsessed by it. Also she's strong willed, and energetic. Good traits for founding 23andMe.
- www.vanityfair.com/style/2014/04/sergey-brin-amanda-rosenberg-affair Fantastic painting of the people.
As www.nytimes.com/2017/11/18/style/anne-wojcicki-23andme-genetics.html puts it well:
The Wojcickis grew into Silicon Valley royalty. It’s the sort of family, Anne jokes, where “you’re only a viable fetus once you have your Ph.D.
Anne Wojcicki interview by Talks at Google (2018)
Source. She's athletic! As mentioned at: www.vanityfair.com/style/2014/04/sergey-brin-amanda-rosenberg-affair. And despite the name, and unlike Sergey, she's completely american as seen from her perfect accent!- youtu.be/pDoALM0q1LA?t=173 coding on garage while they do dishes and burritos
- youtu.be/pDoALM0q1LA?t=331 why she's obsessed with healthcare. Also mentioned at: www.vanityfair.com/style/2014/04/sergey-brin-amanda-rosenberg-affair how she was trying to save Sergei from some of his genetic predispositions
- youtu.be/pDoALM0q1LA?t=571 she really cared about 23andMe, but the public didn't as much as her. She's truly passionate about mining genetic data. Maybe she came a bit early.
- youtu.be/pDoALM0q1LA?t=1038 doc in a box workaround
- foreign keys are capitalized:
- you must give
foreignKeywhen using aliases, otherwise it fails subtely. That would be derived automatically. - stackoverflow.com/questions/41502699/return-flat-object-from-sequelize-with-association can't auto-flatten to reuse the database's
ORDER limitandoffsetdon't work withoutsubQuery: falsewhen doing includes! It is just too buggy. Examples of this can be found e.g. under nodejs/sequelize/many_to_many_same_model.js.- stackoverflow.com/questions/34059081/how-do-i-reference-an-association-when-creating-a-row-in-sequelize-without-assum hard to not duplicate foreign keys values everywhere
- stack traces permanently broken or requiring non-obvious configs:
- does not automatically update fields on hooks: github.com/sequelize/sequelize/issues/8586#issuecomment-422877555
- cannot change columns when other columns have constraints due to the backup table?
- you have to use
.get()forattributealiased fields, why? stackoverflow.com/questions/32649218/how-do-i-select-a-column-using-an-alias/69890944#69890944 .idgets added toSELECTno matter what, breakingGROUP BYunless you do horrible workarounds:- no simple built-in mechanism for transaction retries: Sequelize transaction retries
- impossible to do subqueries in general. Docs just tell you to use literals. This in particular prevents single query deletes with join as done at nodejs/sequelize/raw/many_to_many.js:Also, you can't get query strings either: github.com/sequelize/sequelize/issues/2325
- sequelize.org/master/manual/sub-queries.html: the docs actually just tell you to use literals, lol
- stackoverflow.com/questions/45354001/nodejs-sequelize-delete-with-nested-select-query
- migrations. Generally speaking, anything but the simplest migrations are exceedingly hard to get right, as you have to go very low level when doing migrations. Syntax can be very different from regular DB operations.
- no way to do (non-raw) queries during migrations, e.g. to update fields based on other fields in a complex way?
- github.com/sequelize/cli/issues/862
- stackoverflow.com/questions/18742962/add-data-in-sequelize-migration-script
- stackoverflow.com/questions/38671483/sequelize-migration-update-model-after-updating-column-attributes
- stackoverflow.com/questions/38998397/can-i-use-sequelize-models-in-migration-scripts
- stackoverflow.com/questions/45286429/custom-query-on-sequelize-seeder
queryInterface.sequelize.modelscontains onlySequelizeMeta. Not sure why they have this limitation. - stackoverflow.com/questions/56043246/node-js-sequelize-no-primary-keys-when-migrating/56046101#56046101
- SQLite
changeColumnmigrations do on delete cascades of other tables. SQLite does not have change column statements, so they have to drop and recreate tables, but they don't temporarily remove cascades, so you lose data: stackoverflow.com/questions/62667269/sequelize-js-how-do-we-change-column-type-in-migration/70486686#70486686 - associations require full explicit index construction: stackoverflow.com/questions/39651853/how-to-create-join-table-with-foreign-keys-with-sequelize-or-sequelize-cli
- ability to iterate over a large result without blowing up memory and without using limit + offset (which is inneficient e.g. when looping over recursive queries). This is also known as cursor or streaming interfaces:E.g. the Python SQLite interface supports this just fine: stackoverflow.com/questions/29582736/python3-is-there-a-way-to-iterate-row-by-row-over-a-very-large-sqlite-table-wi
- stack overflow
- stackoverflow.com/questions/28787889/how-can-i-set-up-sequelize-js-to-stream-data-instead-of-a-promise-callback
- stackoverflow.com/questions/43964067/how-to-implement-cursor-pagination-using-sequelize
- stackoverflow.com/questions/57164242/perform-sequelize-findall-in-a-huge-array
- stackoverflow.com/questions/55191891/how-to-loop-through-result-in-sequelize generic loop
- issue tracker
- stack overflow
- empty
attributes: []breaks some nested queries: github.com/sequelize/sequelize/issues/16436 - does not expose a iteration API that supports large arrays?E.g. Python SQLite does: stackoverflow.com/questions/29582736/python3-is-there-a-way-to-iterate-row-by-row-over-a-very-large-sqlite-table-wi
Very raw. Easy to understand. Relatively well organiezd. But also very buggy at 3ab8d9f849a1cdf2985a8d123b1893f0fd4e79ab: github.com/Varun-Hegde/Conduit_NodeJS/issues/3, I just can't trust it. There must be several helper libraries that would greatly DRY up the repetitive CRUD. Ciro hates the style :-) 4 space indents, no space after commas, no semicolon. Not based on github.com/gothinkster/node-express-realworld-example-app which is essentially one of the reference implementations, so from scratch apparently, which is a bad sign.
How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it Sequencing by 
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01 How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it External links to this page by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01- 2021-03-25: Oxford Nanopore Technologies retweeted this article, that's awesome!
- 2021: hackaday.com/author/wd5gnr1/ "SEQUENCING DNA FOR METAGENOMICS" by Al Williams (2021). This came after Ciro Santilli self promoted at: stackoverflow.blog/2021/02/03/sequencing-your-dna-with-a-usb-dongle-and-open-source-code/#comment-1411921
Oxford Master Course in Mathematical and Theoretical Physics by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01Microwave only found applications into the 1940s and 1950s, much later than radio, because good enough sources were harder to develop.
One notable development was the cavity magnetron in 1940, which was the basis for the original radar systems of World War II.
Codaisseur/feathersjs-react-redux-ssr by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01As of 2021, last commit from 2017.
Running:failed on Ubuntu 20.10 Node.js v14.15.3 with:Likely similar bullshit from: stackoverflow.com/questions/50111688/node-sqlite-node-gyp-build-error-no-member-named-forceset-in-v8object because the Node.js version is too new.
git clone https://github.com/Codaisseur/feathersjs-react-redux-ssr
cd feathersjs-react-redux-ssr
npm install../src/create_string.cpp:17:37: error: no matching function for call to ‘v8::String::Utf8Value::Utf8Value(v8::Local<v8::Value>&)’
17 | v8::String::Utf8Value string(value);
| ^If I try
nvm install v10I Google error messages until reaching:and the next problem is: stackoverflow.com/questions/48513573/gulp-error-gulp-hastask-is-not-a-function
diff --git a/gulpfile.js b/gulpfile.js
index b931e06..24d2cc8 100644
--- a/gulpfile.js
+++ b/gulpfile.js
@@ -14,34 +14,34 @@ gulp.task('css', function() {
.pipe(gulp.dest('./dist'))
})
-gulp.task('css:watch', ['css'], function() {
+gulp.task('css:watch', gulp.series('css', function() {
gulp.watch('app/styles/**/*.sass', ['css'])
-})
+}))
gulp.task('moveAssets', function() {
return gulp.src('./app/assets/**/*')
.pipe(gulp.dest('./dist/assets'))
})
-gulp.task('build:revAssets', ['css', 'moveAssets'], function() {
+gulp.task('build:revAssets', gulp.series('css', 'moveAssets', function() {
var rev = new $.revAll()
return gulp.src('./dist/**/*')
.pipe(rev.revision())
.pipe(gulp.dest('./dist/public'))
.pipe(rev.manifestFile())
.pipe(gulp.dest('./dist'))
-})
+}))
gulp.task('build:cpServer', function() {
return gulp.src('./app/**/*.{js,ejs}')
.pipe(gulp.dest('./dist/server-build'))
})
-gulp.task('build:revServer', ['build:cpServer'], function() {
+gulp.task('build:revServer', gulp.series('build:cpServer', function() {
var manifest = gulp.src('./dist/rev-manifest.json')
return gulp.src('./dist/server-build/{components,containers}/**/*')
.pipe($.revReplace({ manifest: manifest }))
.pipe(gulp.dest('./dist/server-build'))
-})
+}))
gulp.task('build', function() {
runSequence('build:revAssets', 'build:revServer')
diff --git a/package.json b/package.json
index bcb29c3..86bd593 100644
--- a/package.json
+++ b/package.json
@@ -67,7 +67,7 @@
"redux-thunk": "^0.1.0",
"request": "^2.79.0",
"rewire": "^2.3.4",
- "run-sequence": "^1.2.2",
+ "run-sequence": "^2.2.1",
"serve-favicon": "^2.3.2",
"socket.io-client": "^1.7.2",
"superagent": "^1.4.0",
@@ -86,16 +86,16 @@
"concurrently": "^2.0.0",
"cross-env": "^1.0.7",
"enzyme": "^2.3.0",
- "gulp": "^3.9.0",
+ "gulp": "^4.0.2",
"gulp-autoprefixer": "^3.1.0",
"gulp-load-plugins": "^1.2.0",
"gulp-rev": "^6.0.1",
- "gulp-sass": "^2.1.1",
+ "gulp-sass": "4.1.0",
"gulp-sourcemaps": "^1.6.0",
"jsdom": "^7.0.1",
"mocha": "^2.4.5",
"nock": "^2.17.0",
- "node-sass": "^3.4.2",
+ "node-sass": "^5.0.0",
"nodemon": "^1.6.0",
"react-addons-test-utils": "^15.3.2",
"react-transform-catch-errors": "^1.0.0",The first gene in the E. Coli K-12 MG1655 genome. Remember however that bacterial chromosome is circular, so being the first doesn't mean much, how the choice was made: Section "E. Coli genome starting point".
Part of E. Coli K-12 MG1655 operon thrLABC.
At only 65 bp, this gene is quite small and boring. For a more interesting gene, have a look at the next gene, e. Coli K-12 MG1655 gene thrA.
Does something to do with threonine.
This is the first in the sequence thrL, thrA, thrB, thrC. This type of naming convention is quite common on related adjacent proteins, all of which must be getting transcribed into a single RNA by the same promoter. As mentioned in the analysis of the KEGG entry for e. Coli K-12 MG1655 gene thrA, those A, B and C are actually directly functionally linked in a direct metabolic pathway.
We can see that thrL, A, B, and C are in the same transcription unit by browsing the list of promoter at: biocyc.org/group?id=:ALL-PROMOTERS&orgid=ECOLI. By finding the first one by position we reach; biocyc.org/ECOLI/NEW-IMAGE?object=TU0-42486.
Transcription factor for E. Coli K-12 MG1655 operon thrLABC as shown at biocyc.org/ECOLI/NEW-IMAGE?object=TU0-42486.
Note that this is very close to the "end" of the genome.
Research group of the Department of physics of the University of Oxford by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01 Superconducting qubits are bad because it is harder to ensure that they are all the same by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01This is unlike atomic systems like trapped ion quantum computers, where each atom is necessarily exactly the same as the other.
Physics course of the University of Oxford by Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01
Ciro Santilli 37 Updated 2025-07-01 +Created 1970-01-01From the 2020/2021 Oxford physics course handbooks we can determine the following structure:
- Year 1 (CP, "Coure Preliminaries", "Prelims"). Take all of:
- CP1 Classical mechanics, Special relativity
- CP2 Electromagnetism, circuit theory and optics
- CP3 Mathematical methods 1. Complex Numbers and Ordinary Differential Equations. Vectors and Matrices.
- CP4 Mathematical methods 2. Multiple Integrals and Vector Calculus. Normal Modes, Wave Motion and the Wave Equation.
- Year 2 (Part A). Take all of:
- A1 Thermal physics. Kinetic Theory, Heat Transport, Thermodynamics.
- A2 Electromagnetism and optics
- A3 Quantum physics. Quantum Mechanics and Further Quantum Mechanics.
- Short options: at least one of:
- Mathematical Methods
- Probability and Statistics
- S01 Functions of a Complex Variable
- S07 Classical Mechanics
- S10 Medical Imaging and Radiation Therapy
- S13 Teaching and Learning Physics in Schools
- S14 History of Physics
- S20 History of Science
- S21 Philosophy of Science
- S22 Language Options
- S25 Climate Physics
- S27 Philosophy of Space-Time
- S29 Exploring Solar Systems
- S33 Entrepreneurship for Physicists
- Year 3 (Part B). Take all of:
- Michaelmas term
- Hilary term
- B1 Fluids
- B3 Atomic and laser physics
- B5 General relativity
- B7 Classical Mechanics (for MPhysPhil only?)
- B8 Computational Project
- B9 Experimental Project
- Year 4 (MPhys). Select two from:
Trinity term, the third and final term of each year, contains mostly revision from the previous two terms, after which students take their final exams, which basically account for their entire grade. Trinity is therefore a very tense part of the year for the students. After that they have summer holidays, until coming back for the next year of madness.
The official external course landing page: www.ox.ac.uk/admissions/undergraduate/courses/course-listing/physics. 2021 archive: web.archive.org/web/20221208212856/https://www.ox.ac.uk/admissions/undergraduate/courses/course-listing/physics) In those pages we see the rough structure, except that it does not have the course codes "A1" etc., and some courses are missing.
At web.archive.org/web/20221229021312/https://www2.physics.ox.ac.uk/sites/default/files/2011-06-03/course_v3_pdf_80151.pdf page 11 we can see the global course structure giving the two options, 3 year BA or 4 year Oxford physics masters:
Year 1
(Prelims)
|
|
v
Year 2
(Part A)
|
+-----------+
| |
v v
Year 3 BA Year 3 (MPhys)
(Part B) (Part B)
| |
| |
v v
BA Year 4
(Part C)
|
|
v
MPhysPractical courses notes: www-teaching.physics.ox.ac.uk/
Some others with lecture notes:
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