{tag=SARS-CoV-2 cell entry}
{wiki}

= ACE2
{c}
{synonym}

<UniProt> <human>: https://www.uniprot.org/uniprot/Q9BYF1 It is interesting to see in the Mutagenesis how many known mutations can increase or decrease <SARS-CoV-2 S protein> binding affinity.

<Receptor (biochemistry)> in <SARS-CoV-2 cell entry>.


Angiotensin-converting enzyme 2

{c}

https://www.youtube.com/watch?v=6DxlkxA82FM COVID-19 Symposium: Entry of Coronavirus into Cells | Dr. Paul Bates

Interaction points:
* <ACE2>
* <TMPRSS2>

\Video[https://www.youtube.com/watch?v=e2Qi-hAXdJo]
{title=Model of Membrane Fusion by <SARS-CoV-2 S protein>[SARS CoV-2 Spike Protein] by <clarafi> (2020)}


SARS-CoV-2 cell entry

{c}
{title2=spike}

Spike.

Nucleocapsid phosphoprotein, sticks to the <RNA> inside.

https://www.nature.com/articles/s41467-020-20768-y mentions functions:
* helps pack the viral RNA into the capsule
* also has a side function in immune suppression


Ciro Santilli @cirosantilli 37

 Incoming links: SARS-CoV-2 S protein