The canonical undecidable problem.
Once you hear about the uncomputability of such problems, it makes you see that all Diophantine equation questions risk being undecidable, though in some simpler cases we manage to come up with answers. The feeling is similar to watching people trying to solve the Halting problem, e.g. in the effort to determine BB(5).
mathoverflow.net/questions/11540/what-are-the-most-attractive-turing-undecidable-problems-in-mathematics/103415#103415 provides a specific single undecidable Diophantine equation.