Host-cell reactivation (HCR) is a cellular mechanism that allows for the repair and recovery of damaged DNA within cells, particularly in response to DNA damage that occurs during the replication of viruses or following exposure to certain stressors, such as UV radiation or chemical agents. The basic tenet of host-cell reactivation involves the uptake of viral DNA that has been damaged and its subsequent repair by the host cell's repair machinery. It highlights the interplay between viral infections and host cellular processes.
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