The NMDA receptor (N-Methyl-D-Aspartate receptor) is a type of ionotropic glutamate receptor that plays a key role in synaptic plasticity, memory formation, and learning in the brain. It is a crucial component of the excitatory neurotransmitter system in the central nervous system. Key characteristics of NMDA receptors include: 1. **Activation**: NMDA receptors are activated by the binding of glutamate, the primary excitatory neurotransmitter in the brain.
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An NMDA receptor is an ionotropic receptor gating an ion channel with voltage-dependent magnesium block. This voltage dependence permits cooperative amplification when inputs produce sufficient local depolarization; calcium can also pass through the open channel.[ref]