The Random Coil Index (RCI) is a quantitative measure used to describe the intrinsic conformational properties of polypeptides or proteins in solution, particularly the propensity of certain amino acid sequences to adopt random coil (or disordered) conformations. It provides insights into the structural characteristics of proteins that do not have a well-defined three-dimensional structure, often referred to as intrinsically disordered proteins (IDPs) or regions within proteins.
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