Ryanodine receptor 1 (RyR1) is a calcium release channel located in the sarcoplasmic reticulum (SR) of skeletal muscle cells. It plays a critical role in the process of muscle contraction by releasing calcium ions (Ca²⁺) into the cytoplasm when the muscle is stimulated. This released calcium then binds to proteins such as troponin, leading to muscle contraction through the sliding filament mechanism.
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