Voltage-gated calcium channels (VGCCs) are a type of ion channel found in the membranes of excitable cells, such as neurons and muscle cells. They open in response to changes in the membrane potential, allowing calcium ions (Ca²⁺) to flow into the cell when the membrane is depolarized.
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A voltage-gated calcium channel couples membrane voltage to a calcium-permeable pore. In a pancreatic beta cell, depolarization-dependent calcium entry can connect metabolic sensing to insulin-granule exocytosis.