Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Villification in the mouse: Bmp signals control intestinal villus patterning by Katherine D. Walton and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Katherine D. Walton and coauthors.
Cited material: BMP perturbations in intestinal explants and species comparison.
Identification of stem cells in small intestine and colon by marker gene Lgr5 by Nick Barker and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Nick Barker and coauthors.
Cited material: Inducible Lgr5 lineage tracing.
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche by Toshiro Sato and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Toshiro Sato and coauthors.
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters by Paul W. Tetteh and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Paul W. Tetteh and coauthors.
Dedifferentiation of committed epithelial cells into stem cells in vivo by Purushothama Rao Tata and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Purushothama Rao Tata and coauthors.
Cited material: Airway basal-cell ablation, secretory-lineage tracing and coculture.
Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status by Iwo Kucinski and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Iwo Kucinski and coauthors.
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation by David Fernandez-Antoran and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
David Fernandez-Antoran and coauthors.
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium by Makoto Horiuchi and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Makoto Horiuchi and coauthors.
Positional information and the spatial pattern of cellular differentiation by Lewis Wolpert by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Cited material: Positional specification and interpretation framework.
Sonic hedgehog mediates the polarizing activity of the ZPA by Robert D. Riddle and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Robert D. Riddle and coauthors.
Cells keep a memory of their tissue origin during axolotl limb regeneration by Martin Kragl and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Martin Kragl and coauthors.
Cited material: Transgenic tissue grafts and lineage-restricted contributions.
Vitamin A and pattern formation in the regenerating limb by Malcolm Maden by
Codex 0 Created 2026-10-20 Updated 2026-10-31
FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration by Eugen Nacu and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Eugen Nacu and coauthors.
Cited material: Anterior-posterior signals and replacement of tissue interactions.
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation by Owen W. J. Prall and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Owen W. J. Prall and coauthors.
Multiple essential functions of neuregulin in development by Dirk Meyer and Carmen Birchmeier by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Cited material: Neuregulin-null embryonic phenotypes.
Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size by Todd Heallen and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Todd Heallen and coauthors.
Cited material: Cardiac conditional mutants and beta-catenin genetic interaction.
Transient regenerative potential of the neonatal mouse heart by Enzo R. Porrello and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Enzo R. Porrello and coauthors.
Cited material: Age comparison, cardiac apex resection and fate mapping.
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis by Aron B. Jaffe and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Aron B. Jaffe and coauthors.
Cited material: Caco-2 cysts, depletion experiments and spindle orientation.
Patterned gene expression directs bipolar planar polarity in Drosophila by Jennifer A. Zallen and Eric Wieschaus by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Cited material: Planar cortical organization during germband extension.
Pulsed contractions of an actin-myosin network drive apical constriction by Adam C. Martin and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Adam C. Martin and coauthors.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





