 Allele-frequency estimator under Hardy-Weinberg equilibrium

ID: allele-frequency-estimator-under-hardy-weinberg-equilibrium

From genotype counts in

n

independent diploid individuals, the unbiased and maximum-likelihood estimator of the frequency of allele

B

θ = \frac{2 n _{BB} + n _{A B}}{2 n} .

It is the sample proportion among the

2 n

sampled alleles, so it is consistent and

n (θ - θ) d N (0, \frac{θ ( 1 - θ )}{2}) .

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