Ascl2 is a basic helix-loop-helix transcription factor associated with intestinal stem-cell identity and regeneration. Its activity can help differentiated-lineage descendants reacquire a stem-like programme after injury. This is a conditional regenerative response, rather than proof that every Ascl2-expressing cell has unlimited self-renewal. Genetic perturbation and lineage measurements connect the regulator to the recovery process. [ref]
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells by Kazutaka Murata and others. 2020, injury-associated dedifferentiation and Ascl2 dependence
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