David S. Hong investigated delivery of a miR-34a mimic in the phase1 MRX34 study in patients with advanced solid tumours. Encapsulation in a liposome linked a proposed microRNA intervention with the separate experimental problem of delivering an RNA molecule in the body.[ref]
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours by David S. Hong and others. 2020, phase1 study: liposomal miR-34a mimic; preserve study-specific scope and adverse-event discussion when developing further
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