 Glucagon-like peptide-1 receptor

The glucagon-like peptide-1 receptor is a G protein-coupled receptor activated by GLP-1, an intestinal peptide signal. In pancreatic beta cells, it can enhance glucose-dependent insulin secretion, prominently through cyclic AMP-linked pathways. It is distinct from the glucagon receptor despite their related ligands and receptor family. Tissue expression and physiological context determine which downstream response dominates. ^[ref]