 Inbreeding genotype frequencies

For a biallelic locus with frequencies $p=1-q$ and $q$, and inbreeding coefficient $F$, ancestral-copy identity with probability $F$ gives genotype probabilities $P(AA)=p^2+Fpq$, $P(Aa)=2pq(1-F)$ and $P(aa)=q^2+Fpq$. In the IBD component both copies equal a single ancestral draw; in the remaining component the two ancestral alleles are independent biological population draws. A fully penetrant recessive disease therefore has risk $q^2+Fq(1-q)$.

// Target: biology.bigb