 Left derived functors on an abelian category

For a right-exact additive functor out of an abelian category with enough projectives, apply the functor to a projective resolution and take homology objects. The zeroth derived functor is $F$, positive derived functors vanish on projective objects, and the degreewise split horseshoe lemma produces a long exact sequence from every short exact sequence in an abelian category. The target can be any abelian category, including an opposite category of one.