For a right-exact additive functor out of an abelian category with enough projectives, apply the functor to a projective resolution and take homology objects. The zeroth derived functor is , positive derived functors vanish on projective objects, and the degreewise split horseshoe lemma produces a long exact sequence from every short exact sequence in an abelian category. The target can be any abelian category, including an opposite category of one.
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