Michael S. Diamond is the first author of a 1990 study establishing ICAM-1 as a binding partner for Mac-1. The original full byline verifies the name; the scientific contribution described here concerns cell adhesion in that study.[ref]
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18) by Michael S. Diamond and others. Original first-page byline and Abstract
The team combined purified proteins, engineered biological cells expressing the candidates, and antibody-blocking assays. Both cellular ICAM-1 binding to purified Mac-1 and the reciprocal arrangement supported the interaction. Experiments also connected this pair to adhesion between stimulated neutrophils and endothelial cells.[ref]
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18) by Michael S. Diamond and others. Abstract: reciprocal binding and cell-conjugate experiments
The reciprocal design is the illuminating feature. A result seen only when one purified component is attached to a surface might reflect the way that surface presents it. Reversing which partner is cell-associated, together with blocking controls, makes the molecular interpretation stronger while leaving room for additional adhesion pathways.
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