 Nicotinic acetylcholine receptor

A nicotinic acetylcholine receptor is a pentameric cation-selective channel gated by acetylcholine. Extracellular binding interfaces communicate with a pore lined by M2 helices; transmitter recognition and ion selectivity are different properties.

The nicotinic acetylcholine receptor (nAChR) is a type of ligand-gated ion channel that responds to the neurotransmitter acetylcholine (ACh). These receptors are found in both the central and peripheral nervous systems and play a crucial role in various physiological processes, including muscle contraction and neurotransmission.