The nicotinic acetylcholine receptor (nAChR) is a type of ligand-gated ion channel that responds to the neurotransmitter acetylcholine (ACh). These receptors are found in both the central and peripheral nervous systems and play a crucial role in various physiological processes, including muscle contraction and neurotransmission.
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A nicotinic acetylcholine receptor is a pentameric cation-selective channel gated by acetylcholine. Extracellular binding interfaces communicate with a pore lined by M2 helices; transmitter recognition and ion selectivity are different properties.