Solution

ID: past-exam-of-the-mathematical-and-computational-biology-course-of-the-university-of-cambridge/2025/paper-1/3/c/solution

The total variance is the trace . Retaining two original genes preserves the sum of their marginal variances; the largest choice includes the third gene and either of the first two, giving . Thus the largest proportion is 70%. This refers to retaining measured coordinates themselves, rather than replacing them by linear combinations as in principal component analysis.

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