Solution

ID: past-exam-of-the-mathematics-course-of-the-university-of-cambridge/2006/iii/paper-45/1/b/ii/solution

Without genotyping error, the observed genetic marker genotype is a deterministic function of the underlying phase-known genotype. In particular can forget chromosome phase and parental origin. Therefore
Several different phased haplotype pairs can receive factor 1 when the observed multilocus genotype is unphased. With laboratory error, missing alleles or uncertain calls, replace the indicator by an error or observation model. A wholly unobserved genetic marker contributes factor 1. Thus a 0-or-1 factor reflects perfect observation of a deterministic genetic marker state, not a general property of every genetic measurement.

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