Newton's first law says that an unforced body maintains uniform straight-linemotion in an inertial frame. It can function partly asa criterion for identifying inertial frames, but that does not automatically empty it of empirical content. The substantive claim is that there is a common class of frames in which independently isolated bodies have this behavior, rather than needing a different accelerated frame for each trajectory.
A simple counter to the claim that any coordinate choice suffices is a rotating laboratory: free bodies generally have velocity-dependent Coriolis accelerations and cannot all be made uniformly rectilinear by calling that rotating frame inertial while retaining the same force account. Conversely, no finite experiment establishes complete isolation or exact uniform motion forever. The law is tested as part of a network of force laws, geometrical assumptions and clock/ruler procedures, and may have local rather than global validity in a gravitational theory.