UPF2 is an adaptor protein in nonsense-mediated decay that interacts with UPF1 and UPF3. These interactions help couple the context of an RNA-protein assembly to activation of the decay pathway. The role is regulatory and organizational rather than simply recognizing a particular three-base stop codon in isolation. Different substrates can depend differently on individual surveillance components. [ref]
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon by Jens Lykke-Andersen and others. 2000, UPF protein interactions and tethering-dependent decay
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