Lysozyme structure resolution (1965)

With X-ray crystallography by David Chilton Phillips. The second protein to be resolved fter after myoglobin, and the first enzyme.

Published at: Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution (1965). The work was done while at the Davy Faraday Research Laboratory of the Royal Institution.

Phillips also published a lower resolution (6angstrom) of the enzyme-inhibitor complexes at about the same time: Structure of Some Crystalline Lysozyme-Inhibitor Complexes Determined by X-Ray Analysis At 6 Å Resolution (1965). The point of doing this is that it points out the active site of the enzyme.

www.nature.com/articles/206757a0 on Nature 181, 662-666. Paywalled as of 2022. Has some nice pictures in it.

www.nature.com/articles/206761a0 on Nature 206, 761-763. Paywalled as of 2022. Has some nice pictures in it.