Located in Washington, in a dry place the middle of the mountainous areas of the Western United states, where basically no one lives. The Columbia river is however nearby, that river is quite large, and provided the water needed by their activities, notably for cooling the nuclear reactors. It is worth it having look on Google Maps to get a feel for the region.
Unlike many other such laboratories, this one did not become a United States Department of Energy national laboratories. It was likely just too polluted.