AcrB is a bacterial proton-coupled multidrug transporter that functions as part of the AcrAB–TolC export assembly. Its asymmetric trimer and multiple drug-binding regions are structural models for studying broad specificity.[ref]
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism by Satoshi Murakami and others. Figs. 1–5, drug-bound asymmetric AcrB trimer
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