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Joined 2026-09-21 Message
Incoming links: ADP-ribosylation
ADP-ribosylation 2026-11-05
ADP-ribosylation transfers an ADP-ribose group from NAD+ to a target, commonly a protein, with release of nicotinamide. It is a post-translational modification distinct from phosphorylation: the transferred chemical group is different, as are the enzymes that add or remove it. A modification can alter a target's activity or interactions without changing its encoded protein sequence. [ref]
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase by D. M. Gill and others. 1978, abstract and pp. 3050–3054: toxin-dependent protein modification and adenylate-cyclase activity
The cholera toxin experiments linked NAD+-dependent modification of a membrane-associated protein to persistent activation of adenylyl cyclase. They provide a concrete example of how a covalent chemical change can amplify a cellular signal. Other ADP-ribosylation systems have different targets and outcomes, so the chemical name alone does not specify one biological response.
D. M. Gill Created 2026-10-20 Updated 2026-11-05
Researcher studying bacterial toxins and cellular signaling. D. M. Gill and collaborators investigated how cholera toxin catalyzes ADP-ribosylation of membrane proteins and activates adenylyl cyclase, connecting a chemical modification with toxin action.[ref]