Antonino S. Rocha investigated transport in the kidney, including how the thick ascending limb of the Loop of Henle handles sodium chloride and water. A 1973 study with Juha P. Kokko tested isolated rabbit nephron segments under controlled perfusion conditions.[ref]
Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport by Antonino S. Rocha and Juha P. Kokko. Byline and Abstract: isolated medullary thick ascending limbs
Increasing the surrounding osmolality produced essentially no net fluid movement in the tested segments, whereas the outgoing tubular fluid became more dilute under suitable perfusion conditions. Measurements of sodium and chloride concentrations supported removal of sodium chloride from the lumen without an accompanying large water flux.[ref]
Sodium chloride and water transport in the medullary thick ascending limb of Henle. Evidence for active chloride transport by Antonino S. Rocha and Juha P. Kokko. Abstract: imposed osmotic gradients, near-zero net fluid transport and reduced effluent ion concentrations
The illuminating result is a separation of salt and water transport. Removing dissolved material while leaving most of the water behind can dilute tubular fluid and help build a concentrating environment around the tubule. The measured transport properties are distinct from identifying every molecular transporter responsible; the paper's historical chloride-pump interpretation should not be treated as a complete modern molecular account.
Articles by others on the same topic
There are currently no matching articles.