Tail-volume loss and ratio inflation in truncated expiration connects unrecorded late gas to a biased FEV1 to FVC ratio. Suppose a valid first-second volume is retained, the recorded total is , and additional uncollected volume is . The complete ratio is , while using as FVC gives .
If independent information bounds , then
For an original example with L, L and L, the complete ratio lies between 0.60 and 0.80 under this bound. This is a deterministic interval conditional on the tail bound, not automatically a statistical confidence interval.
Bounding uncollected expiratory volume from terminal flow adds a model. Let volumetric flow rate after the stop time be . The missing volume is
If , this gives . For stipulated terminal volumetric flow rate and s, the bound is 0.20 L. With the same and , the ratio is then between 0.75 and 0.80.
The bound extends to a positive sum of exponential tails: if each component has terminal volumetric flow rate and time constant at most , then . Without a justified upper time scale, however, very small terminal volumetric flow rate can coexist with a large slowly emptying volume. A visually flat trace alone does not supply that missing assumption.
The relative inflation from using the truncated ratio is especially simple:
for positive . In the bounded 0.20 L example it is at most . The result assumes termination after a valid first second; an invalid numerator needs another error model.
The primary spirometry standard evaluates end of forced expiration and distinguishes it from the validity of FEV1.[ref] The calculations explain sensitivity to lost tail volume rather than replace the standard's actual maneuver criteria.