Cancer invasion is penetration of cancer cells into surrounding tissue across the normal boundaries of their compartment. It is distinct from cell proliferation and from completion of distant metastatic colonization.
Invasion by connected or coordinated groups of cancer biological cells rather than only isolated migrants. Leader and follower biological cells can perform different tasks.[ref]
An actin-rich cellular protrusion associated with localized extracellular matrix degradation during invasion. Formation, matrix digestion and whole-cell invasion are related but distinct experimental endpoints.

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